Protofibrillar Aβ in Alzheimer's Disease

17 Feb 2000

Dean? William Klein: Let me start by saying how much I enjoyed the paper by Dean et al. A good read.

Beta-Catenin and PS1

13 Aug 1999

caspase mediated cleavage of PS1 (at a.a. 329 and 341) during apoptosis (Tesco, et al., 1998). FAD

Pin1, Tau and the Cell Cycle in Alzheimer Disease

03 Aug 1999

mitosis[ref.5]). Summary of Paper Under Discussion In the paper being presently discussed, Lu et al. provide data

In Search of γ-Secretase

• 5 Comments

05 May 1999

experiment (Wolfe, et al.) are provocative, but they do not conclusively show whether the presenilins are

Apoptosis in Alzheimer Disease

24 Mar 1999

ultimate cell death. Again, I refer you to our data (Mattson et al., Exp. Neurol. 153:35-48 and Mattson et

Frameshift Mutants of β Amyloid Precursor Protein and Ubiquitin-B in Alzheimer's and Down's Syndrome Patients

28 May 1998

aberrant splicing events exclusively in sporadic ALS patients (Lin et al., 1998). The splice variants were

Alzheimer Presenilins in the Nuclear Membrane, Interphase Kinetochores, and Centrosomes Suggest a Role in Chromosome Segregation

20 Mar 1998

IL-1-positive microglia in DS brain of all ages (Griffin et al, 1989). Mqxia: Hi, nice to be back here. June

Isolation of Single Immunohistochemically Identified Whole Neuronal Cell Bodies from Post-Mortem Human Brain for Simultaneous Anlaysis of Multiple Gene Expression

27 Feb 1998

et al., (Int. J. Neurosci., 1990, 55:81-88.). Question 3) What percentage of the brains that were

Deficiency of Presenilin 1 Inhibits the Normal Cleavage of the Transmembrane Domain of Amyloid Precursor Protein

30 Jan 1998

report by De Strooper et. al., (1),and the accompanying commentary by Haas and Selkoe (2), conclude that